New study predicts better markers of health and less death in vitamin D replete HIV+s

Although the odds of death were not associated with the baseline vitamin D level, they “decreased significantly by 46% for a 2-fold higher level of 25-hydroxyvitamin D,” Dr. Viard reported.

…”Similarly, CRP [C-reactive protein] was higher in cases than in controls at the latest sample for AIDS-events and death, and it was also higher at baseline for people who were going to die.  CD14 levels were higher in cases and in controls for AIDS events and death.”

…CD4 counts increased by 7.00% per year for people deficient in vitamin D and by 11.14% per year for people nondeficient in vitamin D (both   P < .01), but not at all for patients who were severely deficient.

…Asked for perspective on these findings, session cochair Andrea Antinori, MD, from the National Institute for Infectious Disease in Rome, Italy, who was not involved with the study, told  Medscape Medical News that he found the results interesting because “probably we don’t have much information about the role of vitamin D, and more interestingly, not only its role in bone mineral density and fracture in the long term but even in immune activation inflammatory pathways” that can increase other risks, for example, for cardiovascular disease.

In other words, remaining haziness on vitamin D’s immune-enhancing functions makes it hard to discern if AIDS is exclusively or at all caused by HIV.

[Source: Medscape]